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Tiaprofenic
acid belongs to the class of NSAID and is used to ease pain and reduce
inflammation in rheumatic conditions, and also to treat painful conditions such
as sprains and strains, and other muscle or joint injuries.
Tiaprofenic acid belongs to the class of NSAID and is used
to ease pain and reduce inflammation in rheumatic conditions, and also to treat
painful conditions such as sprains and strains, and other muscle or joint
injuries.
Pharmacological class: NSAID
Tiaprofenic acid works by blocking the effect of chemicals
in your body, called cyclo-oxygenase (COX) enzymes. These enzymes help to make
other chemicals in the body, called prostaglandins. Some prostaglandins are
produced at sites of injury or damage, and cause pain and inflammation. By
blocking the effect of COX enzymes, fewer prostaglandins are produced, which means
pain and inflammation are eased.
Oral Adult Dosage: 300 mg every 12 hours
Plasma protein binding of tiaprofenic acid is 97 - 98 %.
Renal excretion accounts for 60 % and plasma half-life is 1.5 - 2 hr.
Common (affecting
between 1 in 10 to 1 in 100):
Uncommon (affecting 1 in 100 to 1 in 1000):
Very Rare (affecting less than 1 in 10,000):
Two multi-centre studies were carried out in general
practice comparing tiaprofenic acid with five other non-steroidal anti-inflammatory
agents (ibuprofen, indomethacin, naproxen, piroxicam and benoxaprofen), one in
rheumatoid arthritis and one in osteoarthritis. Two hundred and seventy-seven
general practitioners provided completed case records for 856 patients, 373
with rheumatoid arthritis and 483 with osteoarthritis. Approximately half of
the patients received tiaprofenic acid and the remainder one of the other
drugs. Results showed that tiaprofenic acid was at least as effective as the
other drugs.1
Tiaprofenic acid is a nonsteroidal anti-inflammatory drug
(NSAID) used in the treatment of patients with rheumatic diseases and other
clinical conditions of pain and inflammation. Like other propionic acid
derivatives, tiaprofenic acid is effective and generally well tolerated.
Comparative studies in patients with rheumatoid arthritis or osteoarthritis
receiving tiaprofenic acid 600 mg/day demonstrated improvements in pain
intensity, duration of morning stiffness, articular index and other clinical
variables which were similar to those achieved with alternative NSAIDs.
Tolerability was also comparable between tiaprofenic acid and other NSAIDs.
Thus, tiaprofenic acid is an established option among the range of NSAIDs used
in the treatment of patients with rheumatic diseases, with efficacy and
tolerability profiles that are relatively well characterized.2
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