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Early intervention with combined biomarkers can revolutionize heart disease prevention and provide a clearer, long-term risk assessment in women.
Supporting the idea of extending cardiovascular risk prevention strategies beyond the traditional 10-year estimates currently used, measuring high-sensitivity C-reactive protein (CRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) levels in healthy U.S. women can predict the risk of cardiovascular events over a 30-year period, as per a study in “The New England Journal of Medicine”.
During this time, 3,662 women out of 27,939 women (average age of 54.7 at the start) experienced their first major cardiovascular event. As found, higher levels of CRP, LDL cholesterol, and lipoprotein(a) were linked to an increased likelihood of experiencing major heart events, including heart attacks, strokes, or cardiovascular-related death. Over the three decades of follow-up, participants with the highest levels of these biomarkers had a significantly greater risk of cardiovascular problems.
This study highlights the importance of early intervention, as these biomarkers provide valuable insight into heart health and could help tailor more effective prevention strategies for women, particularly before major health issues arise. Combining these biomarkers offers a comprehensive way to assess long-term cardiovascular risks and could reshape how we approach heart disease prevention. The findings advocate for expanding primary prevention strategies for atherosclerotic events beyond the traditional 10-year risk estimates.
The New England Journal of Medicine
Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women
Paul M Ridker et al.
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