Categories
Change Password!
Reset Password!
Agomelatine, a melatonin antagonist, exhibits potential as a prophylactic medication for preventing migraine without aura.
In a recent parallel randomized controlled trial encompassing 400 migraine-affected patients, researchers have discovered a promising novel avenue for migraine management. According to the findings, Agomelatine can be utilized to decrease the number of attacks, headache intensity, migraine disability assessment (MIDAS), and mean monthly migraine days (MMD) in those battling migraine. The study, conducted by a team of dedicated scientists, focused on the usefulness of Agomelatine, a melatonin antagonist, in curtailing the severity and frequency of migraine attacks.
This triple-blind study featuring both intervention and control groups, encompassed an assessment of 400 participants. Inclusion criteria involved individuals aged 18 to 60 with episodic migraine headaches without aura, who had not previously undergone preventive treatment. Additionally, participants were not on specific medications for other health conditions. Out of the eligible pool, 100 individuals satisfying the inclusion criteria were enrolled and became part of the study. Volunteers were randomized to either the intervention arm, receiving a daily dosage of 25 mg of Agomelatine, or the control arm, receiving vitamin B1 tablets.
The researchers meticulously investigated the impact of Agomelatine on various migraine parameters, encompassing MIDAS, headache frequency, mean MMD, and headache severity. Before the intervention, there were no profound differences between the two arms regarding headache frequency, mean MMD, headache intensity, and MIDAS. However, after three months of intervention, the findings revealed a meaningful divergence. The intervention group exhibited a notable drop in headache frequency per month (p = 0.009) and mean MMD (p = 0.025) compared to the control group.
Moreover, both groups experienced a noticeable difference in headache severity (p < 0.001) and MIDAS (p < 0.001) between the pretest and posttest, highlighting the positive impact of Agomelatine on migraine outcomes. Therefore, Agomelatine could be a viable and effective preventive therapeutic agent for migraine without aura. The researchers propose further investigations comparing Agomelatine with other preventive drugs for migraine, opening the door to potential advancements in migraine alleviation.
BMC Neurology
The effectiveness of agomelatine on headache severity and frequency in episodic migraine without aura; a parallel randomized controlled trial study
Kourosh Farzin et al.
Comments (0)