EN | UA
EN | UA

Help Support

Back

Are NSAIDs effective and safe for postoperative analgesia in sinonasal surgery?

Sinonasal surgery Sinonasal surgery
Sinonasal surgery Sinonasal surgery

What's new?

NSAIDs effectively relieve post sinonasal surgery pain and prevent nausea without raising the risk of postoperative epistaxis.

Following sinonasal surgery, NSAIDs-treated patients reported fewer side effects, a lower need for rescue drugs, and improved pain scores, according to a systematic review and meta-analysis. The effectiveness and safety of NSAIDs in individuals undergoing sinonasal surgery was the aim of the investigation.

Electronic databases such as MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, CINAHL, and the WHO International Clinical Trials Registry Platform were explored. Comparative observational studies and randomized controlled trials (RCTs) in any language were taken into consideration.

Data extraction, risk of bias evaluation, and screening were carried out. Postoperative pain scores, the need for rescue analgesia, and postoperative adverse events (vomiting/nausea, epistaxis) were the outcomes. Fifteen RCTs (with 1,210 participants) and 2 observational studies were incorporated among 4,661 records.

There was no difference in pain scores between the NSAIDs group and the non-NSAIDs group following endoscopic sinus surgery (standardized mean differences [SMD] 0.44 units better). NSAIDs reduced pain scores during septorhinoplasty compared to non-NSAID regimens (SMD 1.14 units better).

At a relative risk (RR) of 0.45, NSAIDs minimized the requirement for rescue medicine. Moreover, NSAIDs did not raise the risk of epistaxis (RR 0.72) while decreasing the risk of nausea with an RR of 0.62. Hence, the findings offered strong evidence to support NSAIDs consideration for individuals undergoing routine sinonasal surgery.

Source:

International Forum of Allergy & Rhinology

Article:

The benefits and risks of non-steroidal anti-inflammatory drugs for postoperative analgesia in sinonasal surgery: a systematic review and meta-analysis

Authors:

Daniel J. Lee et al.

Comments (0)

You want to delete this comment? Please mention comment Invalid Text Content Text Content cannot me more than 1000 Something Went Wrong Cancel Confirm Confirm Delete Hide Replies View Replies View Replies en ru ua
Try: