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Injections of i-PRF markedly improve gingival thickness in patients with thin gums. Keratinized tissue width improves more noticeably with 4 sessions at 10-day intervals compared to 3 sessions at 7-day intervals.
In a study issued in “BMC Oral Health”, injectable platelet-rich fibrin (i-PRF) injections remarkably boosted gingival thickness, contributing to better gum health. Researchers Mohammad Ibraheem Idris and colleagues conducted an extensive search across 9 databases, including PubMed and Scopus, to identify randomized controlled trials (RCTs) that examined the effects of i-PRF on gingival thickness and keratinized tissue width (KTW) in the buccal anterior region of both jaws in individuals with thin gingival phenotype.
In total, 7 RCTs were incorporated, 5 of which yielded data for meta-analysis. It was observed that i-PRF injections led to a significant increase in gingival thickness (mean difference [MD] ranging from 0.12 mm to 0.38 mm) at all follow-up times. As found, 4 injections substantially increased KTW after 3 (MD = 0.31 mm) and 6 (MD = 0.37 mm) months. However, 3 injections showed no vital change after 1 and 3 months (MD = 0.14 mm at both assessment times).
When compared to i-PRF alone, combining i-PRF with microneedling showed superior improvement in gingival thickness, but there was no pivotal difference in KTW between the two treatments. To sum up, i-PRF use is associated with a prominent increase in gingival thickness. Furthermore, KTW improvement depends on injection frequency, with 4 sessions showing a significant increase and 3 sessions illustrating no significant effect.
BMC Oral Health
Efficacy of the injectable platelet-rich fibrin (i-PRF) in gingival phenotype modification: a systematic review and meta-analysis of randomized controlled trials
Mohammad Ibraheem Idris et al.
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