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Convalescent plasma therapy found to be effective in severe COVID-19 patients

Convalescent plasma therapy found to be effective in severe COVID-19 patients Convalescent plasma therapy found to be effective in severe COVID-19 patients
Convalescent plasma therapy found to be effective in severe COVID-19 patients Convalescent plasma therapy found to be effective in severe COVID-19 patients

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The single dose of convalescent plasma found to be well tolerated and decreased viremia in COVID-19 patients along with improvement in symptoms.

As if now no certain therapy is approved for COVID-19 and trials are being undertaken for the treatment of the pandemic, recent study results revealed that convalescent plasma (CP) potentially improved the clinical outcomes by neutralizing viremia (presence of the virus in the blood) in severe COVID-19 patients.

This prospective study enrolled 10 patients of severe COVID-19 and they were transfused with a single dose of 200 mL CP obtained from recently recovered COVID-19 donors, along with supportive care and antiviral medicines. The primary and secondary end-points were safety and improvement in symptoms of the patients within 3 days after CP infusion respectively.

After CP transfusion, an improvement in symptoms was observed and the level of neutralizing antibody increased rapidly in the patients. Within 3 days saturation of oxyhaemoglobin, lymphocyte counts increased and C-reactive protein decreased. In seven patients the blood viral load was undetectable after transfusion. The CP therapy could be investigated further with larger clinical trials for dose optimization, time point and clinical benefits.

Source:

Proceedings of the National Academy of Sciences of the United States of America

Article:

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

Authors:

Duan K

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