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Both Ketorolac IV and Ibuprofen IV provide effective pain management while minimizing opioid use after surgery.
Intravenous administration of Ketorolac and Ibuprofen have similar outcomes for acute post-surgical pain relief, based on a recent systematic review and meta-analysis issued in “Cureus”.
Abhijit Nair and colleagues compared the efficacy of these two renowned NSAIDs for the management of acute pain after surgical procedures.
Appropriate keywords were used to search PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Central Register of Controlled Trials (CENTRAL), and Ovid. The primary and secondary outcomes were the use of opioids over 24-hours and pain scores, patient satisfaction, need for rescue analgesia and adverse events, respectively. The Review Manager helped determine quantitative meta-analysis, and the GRADE described the strength of the evidence.
Six out of 124 articles met the criteria for inclusion. All the categories had a high risk of bias (evaluated via Risk of Bias 2 [RoB-2] tool). No significant difference was noted between the two drugs in terms of 24-hour opioid consumption (mean difference: -4.72; 95% CI: -5.65, -3.80; P=0.79), as well as secondary outcomes. GRADE evidence was moderate for pain during movement and low for other outcomes.
Despite these findings, the review highlighted significant clinical and statistical heterogeneity, indicating variability in the data. The overall strength of evidence was moderate for pain scores during movement and low for other outcomes, suggesting the need for further research, as concluded.
Cureus
Comparison of Intravenous Ibuprofen Versus Intravenous Ketorolac in Acute Postoperative Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Abhijit Nair et al.
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