Novel Collagen hydrogels for superior wound healing

Incorporating polysaccharides such as macrocyclic oligosaccharides such as β-cyclodextrin (β-CD) into collagen-based hydrogels enhances their efficacy for wound healing. This study by Juan J Mendoza and team focused on synthesizing semi-IPN hydrogels of collagen and β-CD at varying compositions to explore their properties.

Fourier-transform infrared spectroscopy confirmed collagen crosslinking at 1740 cm-1. The hydrogel's mechanical, thermal, and morphological properties, as well as its antibacterial efficacy and cytotoxicity, were evaluated.

Hydrogels with higher β-CD content exhibited increased crosslinking, swelling capacity, and gelation rates.  These hydrogels inhibited E. coli growth and allowed the controlled release of agents like malachite green, methylene blue, and ketorolac, enhancing wound healing and infection control. The hydrogels stimulated cell proliferation and metabolic function without causing harmful effects on the cells. They represent promising candidates for advanced wound dressing applications due to their boosted therapeutic efficacy and safety profile.