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Administering peroral antibiotics after laparoscopic appendectomy for complicated appendicitis markedly boosts patient recovery and shortens hospital stays when compared to intravenous antibiotics.
In a new sub-study from a larger cluster-randomized non-inferiority trial, peroral antibiotics offered a marked improvement in recovery and a reduction in hospitalization after laparoscopic appendectomy for complicated appendicitis in comparison with intravenous antibiotics. This study, published in Langenbeck's Archives of Surgery, investigated the effects of peroral and intravenous antibiotics within fast-track surgery and Enhanced Recovery After Surgery (ERAS) protocols, focusing on their influence on patient-reported outcomes after surgery.
Overall, 54 participants were randomly allocated to two groups: one group received peroral antibiotics for 3 days after surgery (n=23), while the other group was treated with intravenous antibiotics (n=31). The primary outcome was the quality of recovery on day 3 after surgery, measured via the Quality of Recovery-15 (QoR-15) questionnaire. The analysis revealed several key findings:
Hence, peroral antibiotics are not only a viable alternative to intravenous antibiotics for appendicitis but may offer superior benefits in terms of postoperative recovery and shorter hospital stays. These findings support a potential shift in clinical practice, aligning with the principles of ERAS, which advocate for lowering the invasiveness of postoperative care and promoting faster recovery times.
Langenbeck's Archives of Surgery
Postoperative recovery in peroral versus intravenous antibiotic treatment following laparoscopic appendectomy for complicated appendicitis: a substudy of a cluster randomized cluster crossover non-inferiority study
Ahmed Abdirahman Mohamud et al.
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