Plasma and urine indole lactic acid: New biomarkers for CKD and inflammation!

A recent study published in 'Dovepress' examined the variations in plasma and urine levels of indole lactic acid (ILA) and their correlation with inflammation in both chronic kidney disease (CKD) patients and healthy individuals.

In their study, Hao Hong and colleagues included 47 CKD patients and 30 healthy people. They used one-way ANOVA and rank-sum tests for variable distribution, Pearson’s or Spearman’s methods for correlation, and logistic regressions with ROC curves for CKD analysis.

Plasma and urine ILA levels were positively correlated. Higher plasma ILA was associated with increased body mass index, age, creatinine, BUN, triglycerides, and uric acid levels, as well as decreased haemoglobin levels. Urine ILA levels correlated with higher age, creatinine, BUN, and uric acid levels, and lower haemoglobin and albumin levels. CKD showed a significant link with plasma and urine ILA levels, as well as with urea and haemoglobin levels.

Plasma and urine ILA are useful biomarkers for assessing CKD and inflammatory status, showing strong diagnostic promise.