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Post operative pain is significantly reduced by preoperative intravenous corticosteroids

Post operative pain is significantly reduced by preoperative intravenous corticosteroids Post operative pain is significantly reduced by preoperative intravenous corticosteroids
Post operative pain is significantly reduced by preoperative intravenous corticosteroids Post operative pain is significantly reduced by preoperative intravenous corticosteroids

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For patients who go through spinal fusion surgery, preoperative intravenous corticosteroids are potent and recommended analgesic adjuvant for managing acute postoperative pain.

Preoperative introduction of intravenous corticosteroids shows notable efficacy in reducing morphine consumption and postoperative pain, evident from a meta-analysis conducted by the scientists of the Department of Spinal Orthopedics, Jizhong Energy Xingtai Mining Group General Hospital, China.


The CENTRAL, PubMed, Web of Science, Google databases, and Embase were systematically searched from inception to March 29, 2018, to extract the randomized controlled trials (RCTs). The weighted mean difference (WMD) and pooled risk ratio (RR) with corresponding 95% confidence interval (CI) of continuous outcomes (the length of hospital stay, visual analog scale [VAS] scores at 12 h, 24 h, 48 h, and 72 h, and total morphine consumption) and discontinuous outcomes (surgical-site infections along with postoperative nausea and vomiting [PONV]) were generated during the meta-analysis.

A total of ten RCTs were included. The intravenous Corticosteroids showed a statistically meaningful decline in pain VAS scores at 12, 24, 48, and 72 hours as compared to the controls. Along with pain alleviation, intravenous Corticosteroids also showed anti-emetic effects, reduced PONV and length of hospital stay. There was no difference between groups with respect to the occurrence of infection. However, further research is required to analyze the adverse effects associated with intravenous corticosteroids.

Source:

Journal of Investigative Surgery

Article:

Can Preoperative Intravenous Corticosteroids Administration Reduce Postoperative Pain Scores Following Spinal Fusion?: A Meta-Analysis.

Authors:

Huarong Wu et al.

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