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A bidirectional intricate relationship exists between atopic dermatitis and psychiatric ailments.
The outcomes of a study published in "BMC Psychiatry" underscored a significant causal link between atopic dermatitis and a heightened likelihood of autism spectrum disorder. Additionally, it identified bipolar disorder and anorexia nervosa as factors that magnify the chances of developing atopic dermatitis. The aim was to examine the multifaceted genetic interplay between atopic dermatitis and psychiatric ailments using bidirectional two-sample Mendelian randomization.
This analysis utilized summary statistics from extensive genome-wide association studies involving 60,653 atopic dermatitis cases and 804,329 controls. Psychiatric disorder data were sourced independently from the Psychiatric Genomics Consortium, ascertaining separation from atopic dermatitis data sources. The Mendelian randomization analysis employed various methodologies, including the inverse variance weighted method, Mendelian randomization-Egger regression method, simple mode method, weighted median method, and weighted mode method, to comprehensively examine causal connections.
The psychiatric disorders examined included attention deficit hyperactivity disorder (ADHD), bipolar disorder, autism spectrum disorder, anorexia nervosa, tourette syndrome, schizophrenia, anxiety, and major depressive disorder. Notably, individuals with atopic dermatitis were found to be at an increased risk of developing ADHD (Odds Ratio [OR] = 1.116; 95% Confidence Interval [CI]: [1.009, 1.234]; P = 0.033) and autism spectrum disorder (OR = 1.131; 95% CI: [1.023, 1.251]; P = 0.016).
Conversely, liability to ADHD (OR = 1.112;95% CI: [1.094, 1.130]; P = 9.20e-40), anorexia nervosa (OR = 1.1; 95% CI: [1.068, 1.134]; P = 4.45e-10), and bipolar disorder (OR = 1.067; 95% CI: [1.009, 1.128]; P = 0.023) was associated with an escalated risk of atopic dermatitis. Of particular significance is the independent causal association between atopic dermatitis and autism spectrum disorder, highlighting a distinct risk factor for individuals with atopic dermatitis.
Moreover, the study found these causal links to be robust and unaffected by biases of horizontal pleiotropy and heterogeneity. These findings underscored the complex interplay between dermatological and psychiatric conditions and highlighted the importance of addressing atopic dermatitis to potentially prevent and treat psychiatric disorders. Understanding these relationships is pivotal for improving patient care and creating targeted interventions. The implications of this research are far-reaching, potentially informing novel strategies for the prevention and management of both atopic dermatitis and psychiatric disorders. As further investigations unfold, this study marks a pivotal step forward in unravelling the intricate connections between skin health and mental well-being.
BMC Psychiatry
Causal relationships between atopic dermatitis and psychiatric disorders: a bidirectional two-sample Mendelian randomization study
Suqi Cao et al.
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