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Triamcinolone extended-release intraarticular injection: Top choice for knee OA pain

Knee osteoarthritis Knee osteoarthritis
Knee osteoarthritis Knee osteoarthritis

What's new?

Knee osteoarthritis patients can benefit from Triamcinolone ER injections due to their superior and continued pain relief along with extended functional improvement compared to other treatment modalities.

With multiple non-operative treatments available for knee osteoarthritis (OA), a recent study published in ‘The Journal of Arthroplasty’ set out to find which options offer the best relief and functional improvement.

A total of 480 patients with unilateral knee OA from the Innovations in Genicular Outcomes Research Registry, who had previously received non-operative therapies, got one of the six treatments: 

  • Cryoanalgesia with deep genicular nerve block (Cryo-Deep/Both)
  • Cryoanalgesia superficial peroneal nerve block (Cryo-Superficial)
  • Intra-articular hyaluronic acid (IA-hyaluronan) injections
  • Intra-articular nonsteroidal anti-inflammatory drug injections (IA-NSAIDs)
  • Intra-articular corticosteroids (IA-corticosteroid) injections 
  • Intra-articular injections of triamcinolone as extended-release formulation (IA-TA-ER) injections

Outcomes for pain severity and physical function were tracked at various intervals spanning over four months. IA-TA-ER injections led to the lowest pain levels, greatest pain decrease, best functional scores, and highest rate of achieving minimally clinically important difference (MCID) score. Cryo-Deep/Both and IA-corticosteroid injections also showed higher rates of achieving MCID than IA-hyaluronan, IA-NSAIDs and Cryo-Superficial.

Source:

The Journal of Arthroplasty

Article:

Improved Pain and Function with Triamcinolone Acetonide Extended-Release and Cryoneurolysis for Knee Osteoarthritis: Use of a New Real-World Registry

Authors:

Michael A Mont et. al

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