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Yawning and nausea found to be initial symptoms reported after glyceryl trinitrate induced migraine attacks, study reveals

Yawning and nausea found to be initial symptoms reported after glyceryl trinitrate induced migraine attacks, study reveals Yawning and nausea found to be initial symptoms reported after glyceryl trinitrate induced migraine attacks, study reveals
Yawning and nausea found to be initial symptoms reported after glyceryl trinitrate induced migraine attacks, study reveals Yawning and nausea found to be initial symptoms reported after glyceryl trinitrate induced migraine attacks, study reveals

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Early warning signals may be useful as timely warning signs in clinical practice with concentration issues exclusively reported by those who have a migraine-like attack.

As per the outcomes of a recent case-control study issued in PAIN journal, glyceryl trinitrate (GTN) stimulated the naturally occurring premonitory symptoms and portrayed that yawning, nausea, photophobia, and concentration complications are most specific for a forthcoming GTN-prompted migraine-like headache.

Unprompted and pharmacologically provoked migraine attacks are commonly headed by non-headache symptoms known as the premonitory symptoms. Onderwater, Gerrit L.J. et al. systematically assessed premonitory symptoms in patients suffering from migraine and healthy controls after the use of GTN. A semistructured interview evaluating 21 promising premonitory symptoms every 15 minutes in the 5 hours after GTN infusion (0.5 µg/kg/min in 20 minutes) was performed in 34 females with migraine without aura and 24 age-matched female controls.

As found, migraine-like headaches arose in 28 out of 34 (82.4%) migraineurs i.e. the GTN responders. 

Following GTN use, 26/28 (92.9%) responders, 6/6 (100%) nonresponders, and 13/24 (54.2%) controls described at least 1 promising premonitory symptom, refer to the table below:


Table: Non-headache symptoms described following the initiation of GTN infusion.

The migraineurs who developed a migraine-like attack commonly reported concentration issues, yawning, nausea, and photophobia as compared to healthy controls. Of particular interest, concentration issues were exclusively described by those who had a migraine-like attack.

Source:

PAIN

Article:

Premonitory symptoms in glyceryl trinitrate triggered migraine attacks: a case-control study

Authors:

Onderwater, Gerrit L.J. et al.

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