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New update: In-human clinical trial of KCP506 gets regulatory approval for chronic neuropathic pain treatment

New update: In-human clinical trial of KCP506 gets regulatory approval for chronic neuropathic pain treatment New update: In-human clinical trial of KCP506 gets regulatory approval for chronic neuropathic pain treatment
New update: In-human clinical trial of KCP506 gets regulatory approval for chronic neuropathic pain treatment New update: In-human clinical trial of KCP506 gets regulatory approval for chronic neuropathic pain treatment

What's new?

Human clinical trials to assess the effectiveness of first-in-class α9α10 nicotinic acetylcholine receptor antagonist now approved.

As per an announcement by a clinical-stage biotechnology company on 12 August 2020 the Clinical Trial Application (CTA) has been approved in the Netherlands for initiation of a first-in-human clinical trial of KCP506 (first-in-class α9α10 nicotinic acetylcholine receptor (nAChR) antagonist) for chronic neuropathic pain treatment.


The safety and efficacy of KCP506 will be evaluated in healthy individuals in this double-blind, placebo-controlled, single ascending dose and multiple ascending dose study. The phase 1 clinical trials of KCP506 have been scheduled later in 2020. This regulatory approval marks a critical milestone for this organization to evaluate the novel non-opioid in the clinic, mentioned the company’s CEO. KCP506 has been believed to have the probability of a disease-modifying therapy devoid of CNS side effects comprising addiction. The α9α10 nAChR antagonists have confirmed its strong anti-neuroinflammatory, pain-relieving potential and neuroprotective outcomes in many preclinical models. KCP506 have the potential of easing chronic pain progression. Different chronic neuropathic pain comprising of diabetic neuropathy, radiculopathy, chemotherapy-induced peripheral neuropathy may benefit from KCP506.


This biotechnology company collaborated with a subsidiary of Roche in April 2018 dedicated to developing first in class α9α10 nAChR antagonists for chronic pain treatment.

Source:

CISION- PR Newswire

Article:

Kineta Receives Regulatory Approval for Initiation of Phase 1 Clinical Trials of KCP506

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