Analgesic effect of Ketorolac added to Lidocaine for severe arm injury surgery

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Created On: 10/02/2023

A randomized, double-blind clinical study was conducted to assess the analgesic effects of Ketorolac intravenously injected vs when it is added to Lidocaine in the Bier block.

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Key take away

In people undergoing traumatic arm injury surgery, Ketorolac reduces the intensity of postoperative pain and the amount of morphine received by patients.

Background

A randomized, double-blind clinical study was conducted to assess the analgesic effects of Ketorolac intravenously injected vs when it is added to Lidocaine in the Bier block.

Method

Candidates for upper limb orthopedic surgery made up the target population. The patients were randomly allocated to one of the three research groups after being chosen based on the entry and exit criteria.

The degree of pain, the quantity of morphine administered via the intravenous patient-controlled analgesia pump, the occurrence of Morphine and Ketorolac side effects, and the degree of overall patient satisfaction with the anesthesia technique and pain management were contrasted across the groups. Utilizing SPSS statistical software version 21, both descriptive and analytical data analysis were performed.

Result

The 3 study groups were similar and did not differ in any demographic characteristics, both quantitatively and qualitatively. The control group's median tourniquet closure time varied from that of the topical Ketorolac and intravenous Ketorolac groups. When it came to how soon after deflating the tourniquet the first request for painkillers was made, there was no discernible difference between the 3 groups. However, there was a substantial variation in how much morphine each group received.

The significance of the impact of pain intensity between the groups was demonstrated by a comparison of pain intensity based on Numerical Rating Scale (NRS) and taking measurement repetition times into account. No discernible difference was seen between the 3 trial groups in terms of overall satisfaction with the quality of analgesia and anesthesia technique. Ketorolac was administered to all the groups, and none of the groups experienced any complications as a result of its use.

Conclusion

Using Ketorolac minimized the intensity of postoperative pain in the recovery room and transfer to the inpatient ward, and also decreased the amount of morphine received by patients.