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Butorphanol versus Sufentanil for gastrointestinal endoscopy sedation

Butorphanol versus Sufentanil for gastrointestinal endoscopy sedation Butorphanol versus Sufentanil for gastrointestinal endoscopy sedation
Butorphanol versus Sufentanil for gastrointestinal endoscopy sedation Butorphanol versus Sufentanil for gastrointestinal endoscopy sedation

The clinical efficacy (particularly recovery time) of 95% effective dose (ED95) of butorphanol and sufentanil in GI endoscopy has been distinguished in this double-blind, randomized study.

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Key take away

Butorphanol is an analgesic which is commonly used for the management of perioperative pain. In comparison with sufentanil, butorphanol when used along with propofol as anesthesia for GI endoscopy proved to be an outstanding sedation approach which lessens the recovery time.

Background

The clinical efficacy (particularly recovery time) of 95% effective dose (ED95) of butorphanol and sufentanil in GI endoscopy has been distinguished in this double-blind, randomized study.

Method

The study have into divided into 2 sections, i.e. in the first section, the voluntary patients who needed GI endoscopy anesthesia were enrolled to calculate the ED95 of butorphanol and sufentanil needed to achieve successful sedation prior to GI endoscopy via Dixon up-and-down method (sequential method). The second section was a randomized study comprising of 200 cases of painless GI endoscopy patients, randomly allocated in 2 groups (100 patients each) as group B (butorphanol at ED95 dose) and group S (sufentanil at ED95 dose). Propofol was used as a sedative given intravenously in both the groups. Fatigue severity scores, time of recovery, visual analogue scale (VAS), hand grip strength, occurrence of nausea, vomiting and dizziness noted carefully.

Result

Butorphanol and sufentanil at ED95 dose for painless GI endoscopy was found to be 9.07 μg/kg (95% confidence interval: 7.81–19.66 μg/kg) and 0.1 μg/kg (95% CI, 0.079–0.422 μg/kg), respectively. Both of these were good analgesics for GI endoscopy. But, butorphanol had a significantly shorter recovery time as compared to sufentanil (21.26 ± 7.70 versus 24.03 ± 7.80 min).

Conclusion

As concluded, butorphanol 9.07 μg/kg more efficiently provided GI endoscopy sedation as compared to sufentanil.

Source:

BMC Anesthesiology

Article:

Comparison of ED95 of Butorphanol and Sufentanil for gastrointestinal endoscopy sedation: a randomized controlled trial

Authors:

Xiaona Zhu et al.

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