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The interplay between fluctuations in depressive symptoms and arthritis development remains unclear.
Improvement in depressive symptoms is linked with a reduced likelihood of developing arthritis. Worsening of depression can increase the chances of arthritis.
The interplay between fluctuations in depressive symptoms and arthritis development remains unclear. This study explored whether improving or worsening depressive symptoms influences arthritis risk in middle-aged and older adults.
Data from the China Health and Retirement Longitudinal Study (CHARLS) (2011-2018) were used in this study. Depressive symptoms were monitored through the 10-item Center for Epidemiological Studies Depression Scale (CES-D-10) scale. Self-reported arthritis history was also recorded. Cox proportional hazards models assessed the impact of changes in depressive symptoms on arthritis development.
Overall, 8556 participants free of arthritis were incorporated. Depressive symptoms were linked with a 54% heightened risk of developing arthritis. A 1-point increase in CES-D-10 score increased arthritis risk by 4%. Volunteers who had depressive symptoms at baseline but improved by follow-up had a 25% lower arthritis rate.
A 1-point drop in CES-D-10 score over 8 years correlated with a 5% reduced arthritis risk.
On the other hand, participants who developed depression over time had a 66% higher chance of getting arthritis. Every 1-point rise in their depression score raised the arthritis risk by 5%.
Improvement in depressive symptoms reduced the risk of arthritis while worsening depression heightened the risk. This underscored the complex connection between depressive disorders and joint disease.
BMC Geriatrics
Association of improvement and worsening of depressive symptoms with arthritis
Ruxi Liu et al.
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