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A study was conducted for classifying the distinct group of people with axial spondyloarthritis on tumor necrosis factor-alpha inhibitors (TNFi) as per the baseline characteristics with the aid of a clustering algorithm.
Cluster
analysis of people with axial spondyloarthritis using TNFi identified two
distinctive clinical phenotypes. These clusters were found to have different
clinical characteristics, treatment responses, disease activity, and TNFi drug
survival probabilities.
A study
was conducted for classifying the distinct group of people with axial
spondyloarthritis on tumor necrosis factor-alpha inhibitors (TNFi) as per the
baseline characteristics with the aid of a clustering algorithm.
Evaluation
of the clinical characteristics and demographic data of axial spondyloarthritis
people incorporated in the Korean College of Rheumatology Biologics and
Targeted Therapy (KOBIO) registry was done. With the aid of divisive
hierarchical cluster assessment, the patterns of disease manifestations were
investigated. Following clustering, the clinical characteristics of people and
the drug survival of TNFi between the classified groups were examined.
Overall, 1042 people were investigated. The cluster assessment segregated people into 2 groups: (i) The axial group (n = 828) primarily demonstrating isolated axial manifestations, and (ii) Extra-axial group more frequently demonstrating extra-axial symptoms (n = 214). Compared to the axial group, almost all extra-axial symptoms (psoriasis, peripheral arthritis, uveitis, enthesitis) were more frequently reported in the extra-axial group.
Furthermore, the extra-axial group exhibited greater disease activity, later disease onset, and a shorter duration of disease when compared to the axial group. Following one year of TNFi therapy, the two groups demonstrated similar disease activity. When compared to the axial group, the extra-axial group displayed a lower drug survival probability with TNFi, as shown in Figure 1:
The cluster analysis of axial spondyloarthritis people treated with TNFi revealed 2 groups. One group is characterized by isolated axial disorder with longer disease duration and earlier disease onset while the other group is characterized by more frequent peripheral spondyloarthritis features.
Arthritis Research & Therapy
A cluster analysis of patients with axial spondyloarthritis using tumour necrosis factor alpha inhibitors based on clinical characteristics
Seulkee Lee et al.
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