This study aimed to evaluate the association between choice of volatile anaesthetic and initial postoperative respiratory complications and focused on a significant knowledge gap in safety outcomes between these 2 commonly used agents.
Sevoflurane and
desflurane are the most frequently used volatile anaesthetic agents. This
single‐centre cohort study provides a direct comparison of the 2 most commonly
used anaesthetics concerning important safety outcome and postoperative
respiratory complications. And, hence desflurane for maintaining general
anaesthesia did not decrease the risk of respiratory complications after the
operation.
This study aimed to evaluate the association
between choice of volatile anaesthetic and initial postoperative respiratory
complications and focused on a significant knowledge gap in safety outcomes
between these 2 commonly used agents.
A retrospective analysis of non‐cardiac surgery patients who got sevoflurane or desflurane for general anaesthesia maintenance was performed. The link between desflurane exposure (when contrasted with sevoflurane) and the primary outcome of respiratory complications after the operation, expressed as initial post‐extubation desaturation (SpO2 < 90%) or re‐intubation in 7 days was evaluated.
The multivariable regression analyses were used as per confounding factors, like patient, anaesthetic and surgical factors. Obesity (BMI > 35 kg.m−2); old age of more than 65 years; and high risk of respiratory complications along with primary outcome at 24 hours were assessed via propensity-matched, interaction and sub‐group analyses.
Desflurane and sevoflurane were used for 23,830 and 84,608 patients, respectively. As compared to sevoflurane, the patients exposed to desflurane did not demonstrate a reduced risk of postoperative respiratory complications (Table 1).
All sub‐groups of high‐risk patients and
propensity score matched cohort had steady findings.
The use of desflurane use was not linked with
decreased postoperative respiratory complications than with sevoflurane. This
study provides significant data to support organisational decisions concerning
desflurane use in terms of environmental and cost distresses with volatile
anaesthetic agents.
Anaesthesia
A comparison of postoperative respiratory complications associated with the use of desflurane and sevoflurane: a single‐centre cohort study
L. Zucco et al.
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