Dienogest as add-on therapy: Effects on fertility and dysmenorrhea

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Created On: 11/12/2024

Infertility, Endometriosis, Dysmenorrhea

While laparoscopic surgery is useful for treating deep endometriosis, the optimal postoperative management remains debated. This open-label, randomized controlled trial investigated whether using Dienogest after surgery can boost fertility and alleviate menstrual discomfort in infertile women.

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Key take away

In infertile women with deep endometriosis, Dienogest as an add-on therapy is more effective than surgical intervention alone in improving pregnancy rates and dysmenorrhea severity.

Background

Method

Overall, 88 women (age 21-38 years) who underwent surgery for deep endometriosis were enrolled. Three patients did not complete follow-up assessments. After surgery, participants were randomly assigned to two groups: 44 women received Dienogest for three months (Group 1), while 41 women received no treatment (Group 2). The primary endpoint was the pregnancy rate measured nine months post-surgery. The secondary endpoint was menstrual pain intensity assessed before and nine months after surgery.

Result

The pregnancy rate in Group 1 was markedly greater than in Group 2 Additionally, women in Group 1 reported a better reduction in dysmenorrhea intensity when compared to Group 2, as shown in Table 1:

Conclusion

Short-term postoperative use of dienogest (selective progestin) was associated with improvements in spontaneous pregnancy rates and dysmenorrhea severity in infertile patients with deep endometriosis.