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Efficacy and safety of Olopatadine-Mometasone to treat seasonal allergic rhinitis

Seasonal allergic rhinitis Seasonal allergic rhinitis
Seasonal allergic rhinitis Seasonal allergic rhinitis

The purpose of this study was to examine the safety, effectiveness, and pharmacology of the Olopatadine hydrochloride-Mometasone furoate combination for the management of allergic rhinitis.

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Key take away

Intranasal use of Olopatadine hydrochloride-Mometasone furoate remarkably improves rhinitis symptoms and is a viable therapeutic option for short-term seasonal allergic rhinitis.

Background

The purpose of this study was to examine the safety, effectiveness, and pharmacology of the Olopatadine hydrochloride-Mometasone furoate combination for the management of allergic rhinitis.

Method

The following keywords were used to search the ClinicalTrials.gov and PubMed database: Olopatadine hydrochloride, Mometasone furoate, GSP301, and Mometasone + Olopatadine. Clinical trials, safety, and pharmacology-related articles were evaluated.

Result

Two phase II clinical studies showed substantial improvements in instantaneous total nasal symptom score (iTNSS) and reflective total nasal symptom score (rTNSS) with twice-daily and once-daily intranasal Olopatadine-Mometasone. Twice-daily Olopatadine-Mometasone demonstrated considerable enhancements in rTNSS compared to placebo, Olopatadine monotherapy, and Mometasone monotherapy in two phase III clinical studies.

Conclusion

Olopatadine hydrochloride-Mometasone furoate is beneficial to alleviate rhinitis. For some high-risk patients, active tuberculosis, fungal, bacterial, viral, or parasite illnesses, as well as ocular herpes simplex, caution with use is advised. It might be a viable drug for the initial treatment of moderate-to-severe seasonal allergic rhinitis in patients 12 years of age and older due to its immediate and prolonged onset of effect.

Source:

Annals of Pharmacotherapy

Article:

Intranasal Olopatadine: Mometasone in the Treatment of Seasonal Allergic Rhinitis

Authors:

Lauren Lim et al.

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