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Efficacy of antihistamines to treat chronic spontaneous urticaria patients under omalizumab therapy

Efficacy of antihistamines to treat chronic spontaneous urticaria patients under omalizumab therapy Efficacy of antihistamines to treat chronic spontaneous urticaria patients under omalizumab therapy
Efficacy of antihistamines to treat chronic spontaneous urticaria patients under omalizumab therapy Efficacy of antihistamines to treat chronic spontaneous urticaria patients under omalizumab therapy

A study was conducted to explore the effectiveness of as-needed second-generation antihistamines in patients having well-controlled urticaria under omalizumab therapy.

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Key take away

In individuals with well-controlled urticaria under omalizumab therapy, the second-generation antihistamines are effective agents to treat the intermittent symptoms of chronic spontaneous urticaria (CSU). 

Background

A study was conducted to explore the effectiveness of as-needed second-generation antihistamines in patients having well-controlled urticaria under omalizumab therapy.

Method

A total of 53 participants were enrolled in this study (38 females, mean age 41.1 ± 11.4 years). The study includes CSU patients who were given omalizumab therapy (300 mg/4 weeks for at least three months). These patients had well-controlled urticaria and were using second-generation antihistamines only if required.

Utilizing the modified urticaria activity score-twice daily, the efficacy of second-generation antihistamines, alteration in the hives, itch, and total itch-hives scores prior to and after antihistamines were assessed.    

Result

The intake of second-generation antihistamines minimized itch, hives, and total itch-hives scores, as  shown below: 


As noted, the decline in the symptoms was comparable in both the isolated-urticaria and urticaria and angioedema phenotypes. The baseline levels of IgE were positively linked with the decline of the symptom scores. It indicated that in people having a higher baseline total IgE levels, administration of as-needed second-generation antihistamines lowered the symptom scores less. 

Conclusion

In CSU patients with well-controlled urticaria under omalizumab therapy, the second-generation antihistamines effectively decrease symptoms such as itch and hives. The baseline total IgE levels may be utilized as a potential biomarker for the effectiveness of these agents in urticaria patients. 

Source:

Dermatologic therapy

Article:

Effectiveness of as-needed antihistamines in chronic spontaneous urticaria patients under omalizumab treatment

Authors:

Murat Türk et al.

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