EN | UA
EN | UA

Help Support

Back

Efficacy of Corticosteroids in ICU versus non-ICU community-acquired pneumonia patients

Community-acquired pneumonia Community-acquired pneumonia
Community-acquired pneumonia Community-acquired pneumonia

This meta-analysis sought to examine the use of Corticosteroids (a class of steroid hormones) in community-acquired pneumonia (CAP) patients, specifically comparing outcomes between those admitted to the intensive care unit (ICU) and those treated in a non-ICU setting.

See All

Key take away

Corticosteroids lower mortality and mechanical ventilation needs in ICU community-acquired pneumonia patients.

Background

This meta-analysis sought to examine the use of Corticosteroids (a class of steroid hormones) in community-acquired pneumonia (CAP) patients, specifically comparing outcomes between those admitted to the intensive care unit (ICU) and those treated in a non-ICU setting.

Method

PubMed, Cochrane, and SCOPUS were systematically explored from their inception until May 2023 for randomized controlled trials (RCTs). Mortality, the requirement for mechanical ventilation, the necessity for ICU admission, and treatment failure were all part of the primary outcomes. The need for hospital readmission, duration of hospitalization, length of ICU stay, occurrences of gastrointestinal (GI) bleeding, secondary infections, and hyperglycemic events were the secondary outcomes. The random-effects model was used to evaluate the findings, considering a p-value < 0.05 as statistically significant.

Result

Eighteen RCTs with 4472 CAP patients were considered. The use of Corticosteroids significantly reduced mortality rates (RR: 0.66; 95% CI: 0.54, 0.81; P < 0.0001) and the need for mechanical ventilation (RR: 0.57; 95% CI: 0.44, 0.73; P < 0.00001).

Additionally, corticosteroid therapy was linked with a substantial decrease in both ICU (MD: -1.67; 95% CI: -2.97, -0.37; P = 0.01) and hospital stays (MD: -1.94; 95% CI: -2.89, -0.98; P = 0.0001). However, it also led to an increased incidence of hyperglycemic events and hospital readmissions.

Conclusion

Corticosteroids contribute to better outcomes among CAP patients by lowering mortality rates and decreasing the requirement for mechanical ventilation. Additional large-scale RCTs with specific stratifications are suggested.

Source:

Steroids

Article:

Comparing the efficacy of Corticosteroids among patients with community-acquired pneumonia in the ICU versus non-ICU settings: A systematic review and meta-analysis

Authors:

Luis A. Diaz Caballero et al.

Comments (0)

You want to delete this comment? Please mention comment Invalid Text Content Text Content cannot me more than 1000 Something Went Wrong Cancel Confirm Confirm Delete Hide Replies View Replies View Replies en ru ua
Try: