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Epidural anesthesia is vital for emergency cesarean sections (c-sections), with Chloroprocaine and Lidocaine bicarbonate being popular choices. This randomized controlled trial aimed to determine if combining Lidocaine with Fentanyl provided benefits over Chloroprocaine alone.
Compared to 3% Chloroprocaine, 1.73% Lidocaine bicarbonate + 50 μg Fentanyl exhibits a quicker onset and lower rates of hypotension during epidural anesthesia for cesarean sections.
Epidural anesthesia is vital for emergency cesarean sections (c-sections), with Chloroprocaine and Lidocaine bicarbonate being popular choices. This randomized controlled trial aimed to determine if combining Lidocaine with Fentanyl provided benefits over Chloroprocaine alone.
In this study, 102 full-term parturients undergoing elective c-sections were divided into two groups: one received 15 mL of 3% Chloroprocaine and 1 mL of saline (CP group), while the other received 15 mL of 1.73% Lidocaine bicarbonate with 50 μg of Fentanyl (LF group). The onset time to a T6 block was the primary outcome, measured by pinprick assessments every minute.
The following Table 1 summarizes the median onset times for T6 and T8 blocks for epidural anesthesia during c-sections:
In the LF group, there were fewer episodes of hypotension prior to delivery. Additionally, the incidence of block levels reaching ≥ T4 after supplementation was lower in the LF group.
Lidocaine bicarbonate combined with Fentanyl slightly outperformed Chloroprocaine in terms of faster onset time and fewer hypotension episodes during epidural anesthesia for c-sections, suggesting it could be a preferable choice in emergencies.
Frontiers in Pharmacology
Comparison of lidocaine bicarbonate with fentanyl and chloroprocaine for epidural anesthesia during cesarean section: a randomized, controlled, double-blind clinical trial
Jing Yu et. al.
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