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Drug combinations in diabetic neuropathic pain: an experimental validation

Drug combinations in diabetic neuropathic pain: an experimental validation Drug combinations in diabetic neuropathic pain: an experimental validation
Drug combinations in diabetic neuropathic pain: an experimental validation Drug combinations in diabetic neuropathic pain: an experimental validation

Diabetic neuropathy is the most common complication of diabetes mellitus, and the different drug combinations available do not provide effective pain relief.

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Key take away

The nerve disorder arising due to diabetes is known as diabetic neuropathy. Duloxetine, sitagliptin, pregabalin and amitriptyline and the combinations of these drugs to relieve from the diabetic neuropathic pain have been well explained in this study.

Background

Diabetic neuropathy is the most common complication of diabetes mellitus, and the different drug combinations available do not provide effective pain relief. The present study was performed to observe the effect of amitriptyline, duloxetine, sitagliptin, and pregabalin, and their combinations on streptozotocin (STZ)-induced diabetic neuropathy.

Method

Diabetic neuropathy was induced by STZ, and the tail-flick test was used to assess thermal hyperalgesia before and after (at 30, 60, and 120 min) drug administration. One week after STZ administration, the blood glucose level was observed to be in the diabetic range.

Result

Administration of all the drugs except sitagliptin increased the tail-flick latency significantly as compared to control. Further, the drugs amitriptyline, duloxetine, and pregabalin showed significant pain-relieving effect, when either two of them were administered in combination, although the different combinations had varied degree of pain relief. However, sitagliptin was observed to have no effect when administered alone or in combination with the other three drugs.

Conclusion

Therefore, the study provides new insights concerning combined therapy of pain, which further needs clinical exploration.

Source:

Journal of Basic and Clinical Physiology and Pharmacology

Article:

Drug combinations in diabetic neuropathic pain: an experimental validation

Authors:

Chakra Dhar Tripathi et al.

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