Nephrolithiasis (NL) is comprehended to be correlated with gout; but, the comparative studies on risk and risk factors for NL in gout were minimum.
Nephrolithiasis
is a painful condition in which solid material stones get deposited in the
kidney. There are a few studies in history that explain the association and
risk of nephrolithiasis in gout patients. In this study, the incidence rate and
risk factors of nephrolithiasis have been determined in gout patients, and
various demographic characteristics of patients like age and sex were found to
increase the risk of NL in patients with gout.
Nephrolithiasis (NL) is comprehended to be correlated
with gout; but, the comparative studies on risk and risk factors for NL in gout
were minimum. This analysis evaluated (a) overall rate of NL in gout (cases)
and general population controls; (b) risk and risk factors for first-time NL in
cases and controls independently.
The regional healthcare database in western Sweden (VEGA)
was used to found the patients and sex and age-matched controls. The
investigated risk factors like comorbidities and current medication use for
socioeconomic factors and first-time NL were recovered from VEGA and other
national Swedish registers. For patients, follow up started on 1 January 2006
or on the first examination of gout if this appeared later, and for controls on
their index patient's first investigation of gout. Follow up closed on death,
withdrawal or 31 December 2012. The incidence calculations were implemented for
patients and their controls. HRs with the first episode of NL, as a result, was
assessed only in those without previous NL.
The patients exhibited an increased risk of NL by 60%.
None of the regularly used medicines raised the risk of NL among gout patients.
Arthritis Research & Therapy
Incidence of and risk factors for nephrolithiasis in patients with gout and the general population, a cohort study
A. J. Landgren et al.
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