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Insulin pump vs. multiple daily injections for diabetic ketoacidosis in type 1 diabetic children

Diabetic Ketoacidosis Diabetic Ketoacidosis
Diabetic Ketoacidosis Diabetic Ketoacidosis

This retrospective cohort study was performed to evaluate the efficacy of insulin pump (continuous insulin infusion) therapy compared to multiple daily injections (MDI) in managing blood sugar levels and reducing diabetic ketoacidosis (DKA) in pediatric patients with type 1 diabetes.

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Key take away

Administration of insulin pumps may improve glycemic control, aiding future research and clinical practice amid diabetes technological advancements, potentially reducing complications.

Background

This retrospective cohort study was performed to evaluate the efficacy of insulin pump (continuous insulin infusion) therapy compared to multiple daily injections (MDI) in managing blood sugar levels and reducing diabetic ketoacidosis (DKA) in pediatric patients with type 1 diabetes.

Method

This study spanning 24 months was conducted at a diabetic center in Saudi Arabia, focusing on 351 children aged 1 to 14 years diagnosed with type 1 diabetes mellitus.

Result

Out of total diabetic children, 316 (90%) were on MDI and 35 (10%) on continuous insulin infusion (CII).After 6 months, 38 out of the children (12%) following the MDI schedule for diabetes experienced DKA, while 4 children (11.4%) on the CII schedule encountered the same, but was not statistically noteworthy. The haemoglobin A1c (HbA1c) levels were notably higher (on average) in diabetic patients using MDI at 6 and 9 months of monitoring, Table 1:

Conclusion

Children on MDI had higher HbA1c levels than those on CSII, with no significant difference in DKA rates. Longer follow-up is recommended for more precise results.

Source:

Cureus

Article:

Effectiveness of Insulin Pump Therapy Versus Multiple Daily Injections for Glycemic Control and Rate of Diabetic Ketoacidosis Among Children With Type 1 Diabetes Mellitus

Authors:

Nusaybah Alnaim et al.

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