This study was carried out for exploring the link between prenatal vitamin D sufficiency and allergic consequences in early childhood in the enrolled subjects of the randomized controlled study of prenatal supplementation of vitamin D [Vitamin D Antenatal Asthma Reduction Trial].
In females having insufficiency of
vitamin D in the 1st trimester, a defensive effect of 3rd
trimester prenatal vitamin D sufficiency was noted on the incidence of allergic
rhinitis with aeroallergen sensitization at age three and six years.
This study was carried out for
exploring the link between prenatal vitamin D sufficiency and allergic
consequences in early childhood in the enrolled subjects of the randomized
controlled study of prenatal supplementation of vitamin D [Vitamin D Antenatal
Asthma Reduction Trial].
The study recruited 414
mother-offspring pairs with the data of offspring aeroallergen
sensitization available at age six
years. The link between prenatal vitamin D sufficiency status, based on vitamin
D levels estimated in the 1st and 3rd
trimesters, or vitamin D supplementation therapy assignment was
compared with the findings of aeroallergen sensitization, eczema, parent-stated
allergic rhinitis, total IgE, parent-stated allergic rhinitis with aeroallergen
sensitization, sensitization to food, and any sensitization at age three and
six years.
When matched with the late and early insufficiency, early prenatal insufficiency of vitamin D with late sufficiency was linked with the declined occurrence of allergic rhinitis with aeroallergen sensitization at six years (aOR = 0.54) and three years (adjusted odds ratio [aOR] = 0.34)
As found, allergic rhinitis with
sensitization considerably dropped at six years in offspring whose parents were
given high-dose vitamin D (aOR = 0.54) than offspring whose parents were given
low-dose vitamin D. Link of prenatal vitamin D with aeroallergen sensitization
was enhanced in participants having a maternal atopy history and also who
developed asthma.
Prenatal vitamin D sufficiency in
the third trimester exhibits a protective effect on the occurrence of allergic
rhinitis with aeroallergen sensitization in early childhood.
The Journal of Allergy and Clinical Immunology
The Association of Prenatal Vitamin D Sufficiency With Aeroallergen Sensitization and Allergic Rhinitis in Early Childhood
Yih-Chieh S Chen et al.
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