Link of prenatal Vitamin D sufficiency with allergic rhinitis and aeroallergen sensitization

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Created On: 16/08/2021

Link of prenatal Vitamin D sufficiency with allergic rhinitis and aeroallergen sensitization

This study was carried out for exploring the link between prenatal vitamin D sufficiency and allergic consequences in early childhood in the enrolled subjects of the randomized controlled study of prenatal supplementation of vitamin D [Vitamin D Antenatal Asthma Reduction Trial].

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Key take away

In females having insufficiency of vitamin D in the 1^st trimester, a defensive effect of 3^rd trimester prenatal vitamin D sufficiency was noted on the incidence of allergic rhinitis with aeroallergen sensitization at age three and six years.

Background

Method

The study recruited 414 mother-offspring pairs with the data of offspring aeroallergen sensitization available at age six years. The link between prenatal vitamin D sufficiency status, based on vitamin D levels estimated in the 1^st and 3^rdtrimesters, or vitamin D supplementation therapy assignment was compared with the findings of aeroallergen sensitization, eczema, parent-stated allergic rhinitis, total IgE, parent-stated allergic rhinitis with aeroallergen sensitization, sensitization to food, and any sensitization at age three and six years.

Result

When matched with the late and early insufficiency, early prenatal insufficiency of vitamin D with late sufficiency was linked with the declined occurrence of allergic rhinitis with aeroallergen sensitization at six years (aOR = 0.54) and three years (adjusted odds ratio [aOR] = 0.34)

As found, allergic rhinitis with sensitization considerably dropped at six years in offspring whose parents were given high-dose vitamin D (aOR = 0.54) than offspring whose parents were given low-dose vitamin D. Link of prenatal vitamin D with aeroallergen sensitization was enhanced in participants having a maternal atopy history and also who developed asthma.

Conclusion

Prenatal vitamin D sufficiency in the third trimester exhibits a protective effect on the occurrence of allergic rhinitis with aeroallergen sensitization in early childhood.