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The SENZA-PDN study highlighted the usefulness of high-frequency (10 kHz) spinal cord stimulation (SCS) in delivering substantial and lasting pain relief for painful diabetic neuropathy (PDN)-affected patients, along with improved sleep quality and health-related quality of life.
Using high-frequency (10 kHz) spinal cord stimulation offers long-term betterment in hemoglobin A1c, weight, pain, and sleep quality in individuals with painful diabetic neuropathy and type 2 diabetes.
The SENZA-PDN study highlighted the usefulness of high-frequency (10 kHz) spinal cord stimulation (SCS) in delivering substantial and lasting pain relief for painful diabetic neuropathy (PDN)-affected patients, along with improved sleep quality and health-related quality of life. This study examined the secondary effects of 10 kHz SCS on hemoglobin A1c (HbA1c) levels and weight.
Overall, 144 SENZA-PDN volunteers with type 2 diabetes (T2D) and lower limb pain from PDN, treated with 10 kHz SCS during the SENZA-PDN study were enrolled. Over a 24-month period, the alteration in HbA1c, weight, pain intensity, and sleep patterns were assessed. The enrolled subjects were stratified based on preimplantation HbA1c (>7% and >8%) and body mass index (BMI; ≥30 and ≥35 kg/m²).
Those with preimplantation HbA1c >7% and >8% attained a prominent decrease in HbA1c, averaging 0.5% and 1.1%, respectively at 24 months. A substantial mean weight loss of 3.1 kg was noted across the cohort. Those with BMI ≥30 and ≥35 kg/m² attained even greater weight reductions of 4.1 kg and 5.4 kg, respectively. These metabolic improvements were accompanied by pain relief, with a mean reduction of 79.8% in the degree of pain and a 65.2% drop in sleep interference due to pain.
In PDN and T2D-affected people, sustained reductions in HbA1c and weight occurred following 10 kHz SCS, specifically in those having elevated preimplantation HbA1c and BMI. While the mechanisms underlying these benefits remain unclear, the findings suggest potential direct and indirect metabolic advantages alongside durable pain alleviation, underscoring the transformative potential of SCS therapy.
Journal of Pain Research
Treatment of Painful Diabetic Neuropathy with 10 kHz Spinal Cord Stimulation: Long-Term Improvements in Hemoglobin A1c, Weight, and Sleep Accompany Pain Relief for People with Type 2 Diabetes
David C Klonoff et al.
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