Earlier investigations propose that metabolic disturbances might be correlated with the osteoarthritis (OA) development.
Metabolic syndrome (MetS) has been shown to induce
oxidative stress (OxS). This study clarifies the association of MetS with
osteoarthritis and found a shift in the serum of OA patients, as indicator of
of high-grade OxS and dysglycemia and the OA severity and MetS were
independently associated with oxLDL.
Earlier investigations propose that metabolic
disturbances might be correlated with the osteoarthritis (OA) development.
Relationships have been observed among OA and the individual components of
metabolic syndrome (MetS). MetS have been linked with enhanced oxidative stress
(OxS). This study clarifies the MetS components role in OA and to assess the
levels of OxS in OA subjects and in age-matched controls.
A total of 55 individuals with end-stage OA before knee
or hip joint replacement surgery and 55 gender-, body mass index-, age-matched
controls were selected. Serum levels of c-peptide, insulin, cholesterols, OxS
markers, and glucose were noted. Homeostasis model evaluation for insulin
resistance was employed as the proxy measure of insulin resistance.
Kellgren-Lawrence score was used to measure the radiographic severity.
As compared to the controls, OA patients exhibited reduced total
antioxidant capacity, higher oxidative stress index and total peroxide
concentration. Also, the level of C-peptide found higher among OA patients than
the controls. Moreover, OA radiographic severity was individually correlated
with oxidised LDL and LDL-cholesterol.
This analysis explains that end-stage OA subjects have
raised levels of OxS and reduced antioxidant capacity. OA is linked with
dysglycemia and damaged lipid metabolism. Findings of the study emphasise on
the importance of OxS and metabolic disturbances in the OA pathogenesis.
Scand J Clin Lab Invest. 2017 Jul 24:1-7
Metabolic factors and oxidative stress in osteoarthritis: a case-control study.
Tootsi K et al.
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