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Non-steroidal anti-inflammatory drugs (NSAIDs) for cancer-related pain in children and adolescents

Non-steroidal anti-inflammatory drugs (NSAIDs) for cancer-related pain in children and adolescents Non-steroidal anti-inflammatory drugs (NSAIDs) for cancer-related pain in children and adolescents
Non-steroidal anti-inflammatory drugs (NSAIDs) for cancer-related pain in children and adolescents Non-steroidal anti-inflammatory drugs (NSAIDs) for cancer-related pain in children and adolescents

To determine the non‐steroidal anti‐inflammatory drugs (NSAIDs)  effectiveness and adverse effects that treat cancer‐related pain among children and adolescents in any setting.

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Key take away

Non-steroidal anti-inflammatory drugs (NSAIDs) are common drugs that exhibits analgesic and anti-inflammatory effects. They are widely used in treatment of pain and fever in adults as well as pediatric population. It is a Cochrane review study that analysed different randomized double blind controlled trials to assess the effects of NSAIDs in children suffering from chronic pain and evaluated that there are limited RCTs in history related to this context.

Background

To determine the non‐steroidal anti‐inflammatory drugs (NSAIDs)  effectiveness and adverse effects that treat cancer‐related pain among children and adolescents in any setting.

Method

MEDLINE, CENTRAL, and Embase were searched from inception to 21 February 2017 for collecting associated data. The reference lists of retrieved studies and reviews along with online clinical trial registries were also explored. The assessment of studies for eligibility was done by two authors independently. The dichotomous data was used to estimate the risk ratio and number needed to operate for one further event, using standard methods. The evaluation of GRADE was done and planned to design a 'Summary of findings' table.

Result

No studies were suitable for inclusion. Investigators demoted the quality of evidence by three levels due to the shortage of data listed for any outcome.

Conclusion

No evidence was reported that NSAIDs could decrease cancer‐related pain among children and adolescents. 

Source:

Cochrane Database of Systematic Reviews 2017

Article:

Non-steroidal anti-inflammatory drugs (NSAIDs) for cancer-related pain in children and adolescents.

Authors:

Tess E Cooper et al.

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