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The risk of gout in patients with OSA has been examined in this study.
OSA patients are at high risk of gout due to
pathophysiological processes that may cause hyperuricemia and ultimately gout
or due to common risk factors among both ailments. As observed from this study,
the patients with OSA found to have two times of gout risk which vansihed
following adequate statistical adjustment for
heart failure, BMI, recent diuretics use, etc.
The risk of gout in patients with OSA has
been examined in this study.
All patients aged ≥40 years with a 1st
diagnosis of gout from years’ 1987 – 2014 were included in this
population-based case-control study. The gout cases were matched by birth year,
sex, and practice to the non-gout controls. Gout risk with an earlier diagnosis
of OSA was evaluated using conditional logistic regression. The adjustment of
analyses was as per the lifestyle factors, comorbidities, and latest drug use.
Total of 111, 599 were matched with 210,241
controls. OSA patients were at higher risk of gout (OR 1.86; 95%CI (1.71–2.02).
Nevertheless, this relationship vanished after the adjustment for alcohol
consumption and smoking, body mass index (BMI), former heart failure, renal
function, diabetes, and the use of diuretics and additional medicines. Gout
risk was found to increase among women with OSA and patients with heart
failure, renal impairment, or raised BMI.
Following adjustment, the
perceived association between OSA and gout vanished.
Arthrtis Research & Therapy
Obstructive sleep apnea and the risk of gout: a population-based case-control study
Caroline van Durme et al.
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