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Study evaluates epidural ropivacaine effect with or without dexmedetomidine on postoperative pain relief after thoracolumbar spine instrumentation

Study evaluates epidural ropivacaine effect with or without dexmedetomidine on postoperative pain relief after thoracolumbar spine instrumentation Study evaluates epidural ropivacaine effect with or without dexmedetomidine on postoperative pain relief after thoracolumbar spine instrumentation
Study evaluates epidural ropivacaine effect with or without dexmedetomidine on postoperative pain relief after thoracolumbar spine instrumentation Study evaluates epidural ropivacaine effect with or without dexmedetomidine on postoperative pain relief after thoracolumbar spine instrumentation

This study was conducted to compare the efficacy of epidural ropivacaine with and without dexmedetomidine on postoperative pain relief after the thoracolumbar spine instrumentation. 

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Key take away


In patients experiencing surgery for thoracolumbar spine, epidural ropivacaine plus dexmedetomidine displayed superior efficacy concerning postoperative pain relief and patient satisfaction scores as compared to ropivacaine alone. 

Background

This study was conducted to compare the efficacy of epidural ropivacaine with and without dexmedetomidine on postoperative pain relief after the thoracolumbar spine instrumentation. 

Method

Overall, 60 adult subjects (age group of 18-65 years) who were planned to undertake thoracolumbar spine instrumentation were allocated to either Group RD (epidural ropivacaine plus dexmedetomidine) or Group R (epidural ropivacaine plus saline).

The total rescue analgesic usage on days 0, 1, and 2 of the operation were compared. Total patient satisfaction scores and time to first rescue analgesia via the VAS score <4 were examined.

Result

No change between the demographic features of the two groups was found. The mean value of total rescue analgesia usage, mean time to first rescue analgesia, and mean patient satisfaction score RD group and R group as shown in the following Table 1:

 

RD group

R group

Total rescue analgesia usage

162.5±68.4 mg

247.5±48.8 mg

Mean time to first rescue analgesia

594.6±83.0 minutes

103.6±53.2 minutes

Mean patient satisfaction score

4.2±0.7

3.2±0.6

 

During the postoperative phase, no patient exhibited any respiratory depression or sustained motor blockade.

Conclusion

The surgery of the thoracolumbar spine is linked with acute postoperative pain. The efficacy of epidural dexmedetomidine in spine operations has rarely been reported. Given the safety and efficacy of dexmedetomidine, the decreased rescue analgesia usage, enhanced analgesia period, and decreased pain scores, this study too portrayed a combination of epidural ropivacaine and dexmedetomidine to be more effective for the thoracolumbar spine than ropivacaine alone.

Source:

Emergency Medicine Journal: EMJ

Article:

Influence of Epidural Ropivacaine with or without Dexmedetomidine on Postoperative Analgesia and Patient Satisfaction after Thoraco-Lumbar Spine Instrumentation: A Randomized, Comparative, and Double-Blind Study

Authors:

Faisal Qureshi et al.

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