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This randomized controlled trial aimed to compare the impact of ozone therapy versus natural healing on pain reduction and wound healing in palatal sites after free gingival graft (FGG) surgery.
Ozone therapy effectively improves pain and palatal wound healing in patients with mucogingival defects requiring free gingival grafts.
This randomized controlled trial aimed to compare the impact of ozone therapy versus natural healing on pain reduction and wound healing in palatal sites after free gingival graft (FGG) surgery.
The study included 20 patients (18 females, 2 males) requiring FGG surgery for mucogingival defects. Volunteers were randomly allocated into:
Postoperative pain was assessed using the visual analogue scale (VAS, 1-10) for 7 days as the primary outcome. Secondary outcomes included the number of analgesic tablets used, palatal wound healing, and complete re-epithelialization.
Patients in group I had markedly lower pain scores on days 3 and 7, while group II showed a reduction in pain scores on days 21 and 28. Furthermore, group I demonstrated remarkably higher healing index scores on days 7 and 14, as measured by Landry’s healing index, indicating faster wound healing and earlier complete re-epithelialization when compared to group II. Patients in group II took more analgesic tablets than group I during the first postoperative week.
In patients with mucogingival defects who required augmentation using FGG harvested from the palate, ozone therapy successfully attenuated pain in the early postoperative period. Furthermore, gaseous ozone application to the palatal donor wound facilitated complete epithelialization within 2 weeks and accelerated wound healing when compared to conventional periodontal dressing.
Advanced Dental Journal
The effect of Ozone therapy on pain perception after free gingival graft surgery in patients with mucogingival defects. A Randomized Controlled Clinical Trial
Al-Sherbini et al.
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