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Fibromyalgia is characterized by overall pain, extreme tiredness and sleep disturbances, with recent theories suggesting it stems from central sensitization syndromes that lead to increased pain sensitivity and a lack of standardized treatments.
Combining Melatonin and Palmitoylethanolamide lessens fibromyalgia symptoms significantly, enhancing pain relief, sleep quality, and overall quality of life, with lasting effects observed after treatment cessation.
Fibromyalgia is characterized by overall pain, extreme tiredness and sleep disturbances, with recent theories suggesting it stems from central sensitization syndromes that lead to increased pain sensitivity and a lack of standardized treatments. Palmitoylethanolamide and Melatonin have demonstrated analgesic properties in chronic pain disorders, including fibromyalgia, and are considered very safe.
This open-label pilot study examined the effects of combining Palmitoylethanolamide 1200 mg and Melatonin 0.2 mg given daily on pain, sleep quality, and overall well-being in patients with fibromyalgia.
Fifty fibromyalgia patients (based on the 2016 American College of Rheumatology criteria) were treated and assessed at baseline, as well as at 1 month, 3 months, and 4 months (following a 1-month discontinuation) from June 2023 to March 2024. The evaluations included the Visual Analog Scale (VAS) for pain, the Insomnia Severity Index (ISI), the Health Assessment Questionnaire (HAQ) and an evaluation of tender points.
The patients, with an average age of 54.12 years and a female-to-male ratio of 3:1, demonstrated notable improvements in VAS, ISI, and HAQ scores compared to their initial measurements, along with a decrease in tender points at both 1 and 3 months, which persisted at the 4-month mark. There were no adverse events linked with the usage of this combination.
A fixed combination of Palmitoylethanolamide and Melatonin proved to an effective adjunct therapy in fibromyalgia patients.
Nutrients
A Fixed Combination of Palmitoylethanolamide and Melatonin (PEATONIDE) for the Management of Pain, Sleep, and Disability in Patients with Fibromyalgia: A Pilot Study
Riccardo Terribili et al.
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