Rheumatoid arthritis (RA) and metabolic syndrome (Mets) are considered to be diseases with common traits that can increase the risk of cardiovascular disease incidence; studies in other countries examined the relationship between these diseases.
Metabolic
syndrome (Mets) refers to a clustering of specific cardiovascular (CV) disease
risk factors including central obesity, hypertension, high triglycerides, and
low HDL levels whose underlying pathophysiology is thought to be related to
insulin resistance. As epidemiologic data suggest that RA is an independent
risk factor for CV disease, a useful conclusion was drawn to depict the
relationship between RA and Mets which is based on Korea National Health and
Nutrition Examination Survey (KNHANES).
Rheumatoid
arthritis (RA) and metabolic syndrome (Mets) are considered to be diseases with
common traits that can increase the risk of cardiovascular disease incidence;
studies in other countries examined the relationship between these diseases.
However, existing studies did not show consistent results. In the present
study, the relationship between RA and Mets in Koreans was examined using the
data of the 4th and 5th Korea National Health and Nutrition Examination Survey
(KNHANES).
The present study
used the data of the 4th and 5th KNHANES, conducted between 2007 and 2012.Among
25,812 adults aged over 40, 19,893 were selected as study subjects, excluding
5,919 who did not have variable information needed for the analysis. T-test and
chi-square test were used for the analysis of related variables. To determine
the relationship between diagnostic status of RA and Mets, multivariate
logistic regression analysis was performed by controlling confounding
variables, which were selected through literature review and statistical
analysis.
Multivariate
logistic regression analysis was conducted to examine the relationship between
diagnostic status of RA and Mets. When age, education level, average monthly
household income, smoking, alcohol consumption, and level of physical activity
were adjusted, the prevalence of Mets was lower in RA patients (adjusted odds
ratio [aOR], 0.79; 95% confidence interval [CI], 0.65 to 0.96). Multivariate
logistic regression analysis was performed to examine the relationship between
treatment status of RA and Mets. When age, education level, average monthly
household income, smoking, alcohol consumption, and level of physical activity
were adjusted, there was a significant negative correlation in women (aOR,
0.65; 95% CI, 0.44 to 0.96).
The relationship
between RA and Mets showed a significantly negative correlation in Korean
women. The group that received RA treatment showed significantly lower
prevalence of the Mets as compared to the untreated group in Korean RA women.
Korean J Fam Med 2016; 37:44-50
Relationship between Metabolic Syndrome and Rheumatoid Arthritis
Sang-Hyun Lee et al.
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