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Seborrheic dermatitis (SD) is a common inflammatory condition affecting sebum-rich areas like the scalp, with a prevalence of 11.6%. This randomized clinical trial investigated the utility of topical Rosemary extract and topical Ketoconazole lotions in scalp SD.
Both 5% Rosemary extract and 2% Ketoconazole lotions can successfully manage scalp seborrheic dermatitis. Ketoconazole is more efficient in reducing dandruff severity, while Rosemary extract offers better relief from itching.
Seborrheic dermatitis (SD) is a common inflammatory condition affecting sebum-rich areas like the scalp, with a prevalence of 11.6%. This randomized clinical trial investigated the utility of topical Rosemary extract and topical Ketoconazole lotions in scalp SD.
Overall, 42 patients diagnosed with scalp SD were divided into two groups: one group received 5% Rosemary extract lotion while the other received 2% Ketoconazole lotion. Both lotions were used twice daily for about 2 months. The severity of dandruff, itchiness, and quality of life were assessed via the Adherent Scalp Flaking Score, Itchy Quant, and Dermatology Life Quality Index (DLQI), respectively.
Ketoconazole substantially reduced dandruff severity (as per the Adherent Scalp Flaking Score) when compared to Rosemary extract. However, Rosemary extract showed a greater reduction in scalp itchiness at both 1 and 2 months. The statistical analysis showed no significant difference in the reduction of DLQI scores between the study groups at 1 and 2 months after starting treatment, both in crude and baseline-adjusted analyses.
Twice daily topical application of both Rosemary extract and Ketoconazole lotions for 2 months was beneficial for scalp SD management.
Dermatology Practical & Conceptual
Efficacy of Topical Rosemary Extract Lotion Versus Topical 2% Ketoconazole Lotion in the Treatment of Seborrheic Dermatitis: A Double Blind Randomized Controlled Clinical Trial
Maryam Sadat Sadati et al.
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