EN | UA
EN | UA

Help Support

Back

Seasonal variation in acute gouty arthritis: data from Nationwide Inpatient Sample

Seasonal variation in acute gouty arthritis: data from Nationwide Inpatient Sample Seasonal variation in acute gouty arthritis: data from Nationwide Inpatient Sample
Seasonal variation in acute gouty arthritis: data from Nationwide Inpatient Sample Seasonal variation in acute gouty arthritis: data from Nationwide Inpatient Sample

Studies describing seasonal variations in acute gouty arthritis note seasonal variation, but disagree on timing, with most showing a peak in spring months while others show peaks later in the year.

See All

Key take away

Acute gout/gout flare is a disabling inflammatory arthritis causing intense pain. It mostly involves a single joint, but occasionally involves two or more joints. According to this study, the seasonal disparity has been known to effect the acute gouty conditions. 

Background

Studies describing seasonal variations in acute gouty arthritis note seasonal variation, but disagree on timing, with most showing a peak in spring months while others show peaks later in the year. Various theories on the effect of weather and immune system changes on the chronobiology of monosodium urate crystals’ equilibrium and precipitation have been proposed. We aimed to shed light on this question by examining the seasonal variation in the incidence of acute gouty arthritis in the USA using a large inpatient database.

Method

We used the Nationwide Inpatient Sample (NIS) database to identify patients aged ≥18 years with primary diagnosis of acute gouty arthritis (International Classification of Diseases, 9th Revision, Clinical Modification code 274.01) from 2009–2011 during hospitalization. We used the Edwards recognition and estimation of cyclic trend method to study the seasonal variation of the incidence of acute gout and z-test to compare the seasonal incidences.

Result

A total of 28,172 hospitalizations with primary diagnosis of acute gouty arthritis were reported in the USA from 2009–2011. The peak incidence of acute gout was seen in November (peak/low ratio 1.34, 95 % CI 1.29–1.38, p < 0.05). The highest number of hospitalizations was observed in autumn months while the lowest incidence was observed in spring (28.12 vs. 23.13 %, p < 0.001).

Conclusion

The peak incidence of acute gout seems to be in the fall with its peak in the month of November. This seasonality may shed light into the pathophysiology of acute attacks and better management of patients with gout who are at risk of acute attacks.

Source:

Clin Rheumatology

Article:

Seasonal variation in acute gouty arthritis: data from Nationwide Inpatient Sample

Authors:

Paras Karmacharya et al.

Comments (0)

You want to delete this comment? Please mention comment Invalid Text Content Text Content cannot me more than 1000 Something Went Wrong Cancel Confirm Confirm Delete Hide Replies View Replies View Replies ru en
Try: