Stress ulcer prophylaxis in sepsis people at risk of gastrointestinal bleeding

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Created On: 13/12/2021

Stress ulcer prophylaxis in sepsis people at risk of gastrointestinal bleeding

This retrospective cohort study aimed to assess the effects of stress ulcer prophylaxis versus no prophylaxis on patient outcomes in sepsis people at risk for gastrointestinal bleeding.

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Key take away

Stress ulcer prophylaxis demonstrated no impact on hospital mortality, rate of gastrointestinal bleeding, pneumonia, Clostridium difficile infection, and intensive care unit length of stay in critically ill adult people with sepsis who have potential risk factors for gastrointestinal bleeding.

Background

This retrospective cohort study aimed to assess the effects of stress ulcer prophylaxis versus no prophylaxis on patient outcomes in sepsis people at risk for gastrointestinal bleeding.

Method

Using data from Medical Information Mart for Intensive Care III database, a comparison was made between people who were given stress ulcer prophylaxis with proton pump inhibitors or histamine-2 receptor antagonists for ≥three days and people who were given no prophylaxis. For making comparisons between the study groups with equivalent distributions of study variables, propensity score matching was carried out. In-hospital mortality was the major endpoint.

Result

Overall, 7,744 participants were incorporated with 6,656 (86.0%) participants in the stress ulcer prophylaxis group and 1,088 (14.0%) participants in the non-stress ulcer prophylaxis group. A 1:1 propensity score matching created 866 participants in each cohort. In terms of in-hospital mortality, gastrointestinal bleeding, pneumonia, Clostridium difficile infection, or intensive care unit length of stay, there were no profound inter-group differences, as shown in Table 1: