A meta-analysis and systematic review were performed to examine the prevalence of cancer in patients suffering from coronavirus disease (COVID-19). Also, the link of cancer with severe events was assessed that incorporated severe cases judged by clinical symptoms, utilization of intensive care unit services, and death.
Individuals
with cancer and cancer survivors are at a greater risk of developing
coronavirus infection and are also two- to three-fold more likely of suffering
serious events and mortality.
A meta-analysis and systematic
review were performed to examine the prevalence of cancer in patients suffering
from coronavirus disease (COVID-19). Also, the link of cancer with severe
events was assessed that incorporated severe cases judged by clinical symptoms,
utilization of intensive care unit services, and death.
An
extensive literature search was done in the major databases in Chinese and
English. The publication selection and data extraction were done by two
investigators independently. A meta-analysis was utilized to procure estimates
of pooled prevalence of tumor in coronavirus-infected subjects and examine the
link of cancer with serious events, after determining potential heterogeneity,
publication bias, and rectification for the estimates when needed. In total, 38
studies comprising 7094 individuals suffering from coronavirus infection were
incorporated in this analysis.
Pooled prevalence of cancer was
found to be 2.3% overall and 3.2% in Hubei province. Notably, corresponding
estimates were found to be 1.4% and 1.9% after correcting the publication bias.
Cancer was considerably linked with events of serious cases (odds ratio [OR] =
2.20) and death (OR = 2.97) in coronavirus-infected individuals. There were
minimal publication bias and no vital heterogeneity.
Cancer
comorbidity is linked with the risk and severe events of coronavirus infection.
Special measures should be taken to safeguard cancer patients (especially cancer
survivors), with compromised immune systems or underlying health conditions
from coronavirus exposure.
International Journal of Cancer
Cancer associates with risk and severe events of COVID-19: A systematic review and meta-analysis
Yehong Tian et al.
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