A meta-analysis and systematic review were carried out to investigate efficacy of the probiotics to manage patients having gingivitis.
There is a weak evidence to support the usage of probiotics
in lowering inflammatory periodontal parameters in gingivitis.
A meta-analysis and systematic
review were carried out to investigate efficacy of the probiotics to manage
patients having gingivitis.
Databases like CENTRAL, EMBASE, and MEDLINE were extensively searched up to May 2019. The randomized and/or controlled clinical trials were taken into consideration. The studies incorporating ≥10 subjects per group diagnosed with gingivitis were chosen that comparatively evaluated efficacy of probiotics in any form vs. placebo.
In total, 10 double-blind
placebo-parallel randomized controlled trials
were incorporated. Gingival index and bleeding on probing was the major
endpoint while plaque index was the secondary endpoint. The forest plots were
developed reporting weighted mean difference of outcomes along with 95%
confidence intervals (CI).
At the follow-up, the probiotic administration was found to
be effective to treat gingivitis. In patients receiving probiotics, the mean
percentage of bleeding on probing ranged from 11.87% to 21.7%, and in patients
receiving placebo, it ranged from 15% to 33%. Taking into consideration the
impact of Lactobacillus reuteri, the overall mean difference for gingival index
(WMD = -0.48) and plaque index (WMD = 0.18) did not display any vital
significance between both the cohorts.
Probiotics may not be beneficial to treat inflammatory
periodontal parameters in patients suffering from gingivitis.
Australian Dental Journal
Clinical efficacy of probiotics in the treatment of gingivitis: A systematic review and meta‐analysis
Z Akram et al.
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