A randomized controlled trial was carried to assess whether combining COLP in the immediate postoperative period could lower daily opioid usage and post-surgical pain in subjects recovering from spine surgery.
Conditioning with an open-label
placebo (COLP) may serve as a promising adjuvant analgesic therapy to lower
opioid intake in the early postoperative period, without elevating pain.
A randomized controlled trial was
carried to assess whether combining COLP in the immediate postoperative period
could lower daily opioid usage and post-surgical pain in subjects recovering
from spine surgery.
Participants were randomly assigned
either to COLP cohort or treatment as usual (TAU) cohort. Both the cohorts were
given unimpeded access to a typical opioid-based post surgery analgesic therapy.
To determine the therapeutic impact of COLP on daily opioid intake and pain
during the post surgery period from post-surgery day (POD) 1 to POD 17, the
generalized estimating equations method was utilized.
Participants in the COLP arm
consumed about 30% less daily morphine mg equivalents in comparison with
participants in the TAU arm during POD 1-17 (-14.5 daily morphine mg
equivalents). Daily worst pain scores were also reduced in the COLP cohort
(-1.0 point on the 10-point scale). However, a vital difference was not
witnessed in the average daily pain between the arms (-0.8 point).
In individuals recovering from
spine surgery, COLP may serve as a vital adjuvant analgesic therapy to minimize
intake of opioids in the early post-surgery period, without increasing pain.
Pain
https://journals.lww.com/pain/Abstract/9000/Conditioned_open_label_placebo_for_opioid.98153.aspx
Conditioned open-label placebo for opioid reduction following spine surgery: a randomized, controlled trial
K Mikayla Flowers et al.
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