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Infratentorial microbleeds: another sign of microangiopathy in migraine

Infratentorial microbleeds: another sign of microangiopathy in migraine Infratentorial microbleeds: another sign of microangiopathy in migraine
Infratentorial microbleeds: another sign of microangiopathy in migraine Infratentorial microbleeds: another sign of microangiopathy in migraine

Migraine is a risk factor for clinical stroke and for subclinical white matter hyperintensities and infratentorial infarcts.

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Key take away

Migraine has been corresponded with small vessel endothelial damage and hypercoagulability may escort to small vessel disease. Migraine pathophysiology has been explained well in this research dealing with the small vessel involvement.

Background

Migraine is a risk factor for clinical stroke and for subclinical white matter hyperintensities and infratentorial infarcts. These subclinical lesions are linked to small-vessel pathology. Cerebral microbleeds (CMBs) are another biomarker of small-vessel disease but have not yet been studied in migraine.

Method

Identification of CMBs in 63 migraineurs (25 with aura/35 without aura/3 unknown aura status) and 359 controls (aged, 73-85 years) from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) magnetic resonance imaging study. We assessed the modifying role of migraine in the co-occurrence of CMBs, infarcts, and white matter hyperintensity-load.

Result

Infratentorial microbleeds were more prevalent in migraine without aura patients than controls (14% versus 4%). Prevalence of other CMBs, infarcts, and white matter hyperintensities did not differ between groups. Migraineurs with CMBs had more often infarcts than controls with CMBs (65% versus 43%). In comparison with controls with infarcts, migraineurs with infarcts had more commonly CMBs (55% versus 30%).

Conclusion

Migraine, notably without aura, is associated with infratentorial CMBs at older age. CMBs and infarcts co-occur more often in migraine than in controls. This supports the hypothesis of small-vessel involvement in migraine pathophysiology.


Source:

Stroke 2015 Jul;46(7):1987-9

Article:

Infratentorial Microbleeds: Another Sign of Microangiopathy in Migraine

Authors:

Arkink EB et al.

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