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Metabolic factors may contribute to osteoarthritis (OA).
This study played
an important role in distinguishing the radiographic progressors from the non-
progressors of knee osteoarthritis patients. Also, the metabolites have a vital
contribution towards the evolution of osteoarthritis.
Metabolic factors
may contribute to osteoarthritis (OA). This study employed metabolomics
analyses to determine if differences in metabolite profiles could distinguish
people with knee OA who exhibited radiographic progression.
Urine samples
obtained at baseline and 18 months from overweight and obese adults in the
Intensive Diet and Exercise for Arthritis (IDEA) trial were selected from two
subgroups (n = 22 each) for metabolomics analysis: a group that exhibited
radiographic progression (≥0.7 mm decrease in joint space width, JSW) and an
age, gender, and body mass index (BMI) matched group who did not progress
(≤0.35 mm decrease in JSW). Multivariate analysis methods, including orthogonal
partial least square discriminate analysis, were used to identify metabolite
profiles that separated progressors and non-progressors. Plasma levels of IL-6
and C-reactive protein (CRP) were evaluated as inflammatory markers.
Multivariate
analysis of the binned metabolomics data distinguished progressors from
non-progressors. Library matching revealed that glycolate, hippurate, and
trigonelline were among the important metabolites for distinguishing
progressors from non-progressors at baseline whereas alanine,
N,N-dimethylglycine, glycolate, hippurate, histidine, and trigonelline, were
among the metabolites that were important for the discrimination at 18 months.
In non-progressors, IL-6 decreased from baseline to 18 months while IL-6 was
unchanged in progressors; the change over time in IL-6 was significantly
different between groups.
These findings
support a role for metabolic factors in the progression of knee OA and suggest
that measurement of metabolites could be useful to predict progression. Further
investigation in a larger sample that would include targeted investigation of
specific metabolites is warranted.
Osteoarthritis Cartilage 2016 Mar 21
Association of urinary metabolites with radiographic progression of knee osteoarthritis in overweight and obese adults: an exploratory study
R.F. Loeser et al.
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