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Systematic review and meta-analysis: Effectiveness of Brivudine for herpes zoster

herpes zoster herpes zoster
herpes zoster herpes zoster

This meta-analysis evaluated the effectiveness along with the safety profile of Brivudine for post-herpetic neuralgia (the most common complication of shingles or herpes zoster).

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Key take away

Brivudine, an analogue of thymidine, effectively treats herpes zoster without raising adverse reaction risks, and outperforms acyclovir and valaciclovir in reducing postherpetic neuralgia.

Background

This meta-analysis evaluated the effectiveness along with the safety profile of Brivudine for post-herpetic neuralgia (the most common complication of shingles or herpes zoster).

Method

The data from randomized controlled trials with the use of Brivudine for herpes zoster were gathered from various databases, including Cochrane Library, China National Knowledge Infrastructure, PubMed, Embase, China Science Journal Database, and WanFang Database, covering literature up to September 12, 2022.

Result

This analysis comprised of 7 randomized trials, involving 2095 patients in the experimental group with Brivudine given orally and; 2076 patients in the control group.

Results indicated that the Brivudine group demonstrated superior efficacy (p = .0002) and a lower incidence of post-herpetic neuralgia (p = .04) compared to the control group. The occurrence of adverse responses was similar in both groups. Furthermore, subgroup analysis of adverse events advocated that Brivudine had a comparable safety profile to other treatment modalities for HZ.

Conclusion

Although the evidence regarding the safety of Brivudine remains inconclusive, its efficacy in the treatment of herpes zoster is well-established.

Source:

The Journal of Dermatological Treatment

Article:

Efficacy and safety of Brivudine for the treatment of herpes zoster: a systematic review and meta-analysis

Authors:

Jiaxing Chen et al.

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