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Inflammation in low back pain may be detected from the peripheral blood: suggestions for biomarker

Inflammation in low back pain may be detected from the peripheral blood: suggestions for biomarker Inflammation in low back pain may be detected from the peripheral blood: suggestions for biomarker
Inflammation in low back pain may be detected from the peripheral blood: suggestions for biomarker Inflammation in low back pain may be detected from the peripheral blood: suggestions for biomarker

Biomarker for prediction of development of low back pain, and disease progression in chronic conditions are virtually non-existent.

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Key take away

Low back pain is most frequently observed throughout the world, but the basis for low back pain is poorly understood. The researchers of this present study furnished many novel evidences regarding the mechanisms of neuro-immune inflammation that occurs with low back pain.

Background

Biomarker for prediction of development of low back pain, and disease progression in chronic conditions are virtually non-existent.

Method

In the present study, we examined evidence of inflammation in the peripheral blood and demonstrated significant changes in neuroinflammation markers in subjects with chronic low back pain in comparison to control subjects. The present study was performed using peripheral blood from subjects with chronic low back pain and age-matched control subjects. Western blotting, real-time RT-PCR, cell culture and in vitro assays were incorporated to perform the current study.

Result

We obtained evidence that the balance between proinflammatory and anti-inflammatory cytokines is misaligned, with decrease in interleukin-10 (IL-10) expression and increase in interleukin-6 (IL-6) expression. Furthermore, we demonstrated increase in CD16 monocyte expression. Cells were cultured under differential conditions to generate M1/M2 macrophages. In the macrophages, opioid secretory capacity was shown to be diminished. Finally, Dragon (repulsive guidance molecule b, RGMb) expression was shown diminished in M1 macrophages, which serves as a key transcriptional inhibitor of IL-6 expression.

Conclusion

These biochemical and cellular alterations in chronic low back pain can serve as potential biomarkers for assessing disease initiation, intensity and progression.

Source:

Bioscience Reports

Article:

Inflammation in low back pain may be detected from the peripheral blood: suggestions for biomarker

Authors:

Yong Li et al.

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