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Monitoring 25(OH)D levels in systemic lupus erythematosus pregnancies is recommended, aiming for 40-59 ng/mL, without over-supplementation.
Although not causal, both low and high levels of vitamin D pose a potential risk during pregnancy in women with systemic lupus erythematosus, a recent study published in “Arthritis Care & Research” illustrated. Researchers from the Hopkins Lupus Cohort analyzed data from pregnant lupus patients, assessing their 25-hydroxyvitamin D [25(OH)D] levels at each visit. The outcomes such as miscarriage, preterm delivery, and small-for-gestational-age births were monitored.
The results showed significantly higher risks of miscarriage and preterm delivery in women with either low or high vitamin D levels, with the highest risks seen in those with very low levels during the second trimester. Nine out of ten patients with low vitamin D in the second trimester experienced premature deliveries.
As suggested by the study, maintaining 25(OH)D levels within an ideal range of 40 to 59 ng/mL could potentially reduce these risks, advising regular monitoring of maternal vitamin D levels throughout pregnancies in women with systemic lupus erythematosus. While body mass index did not appear to influence the results, further research is required to clarify the role of high vitamin D levels in pregnancy outcomes.
Arthritis Care & Research
Association Between 25-hydroxyvitamin D Levels and Adverse Pregnancy Outcomes in Systemic Lupus Erythematosus
Nima Madanchi et al.
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