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Rheumatoid arthritis amplifies eosinophilic inflammation, heightening the chances of postoperative recurrence in patients suffering from CRSwNP .
A retrospective cohort study uncovered a critical link between rheumatoid arthritis (RA) and escalated recurrence of chronic rhinosinusitis with nasal polyps (CRSwNP). Highlighting the role of tissue eosinophilic inflammation, the research provided a fresh perspective on tackling postoperative recurrence in this complex patient population.
Researchers analyzed CRSwNP-affected individuals who underwent functional endoscopic sinus surgery. Over a 2-year follow-up, participants were divided into RA and non-RA groups, as well as recurrent and non-recurrent cohorts. The study investigated the impact of RA on tissue inflammation and its influence on recurrence risks. Overall, 517 CRSwNP sufferers were enrolled, of whom 78 had RA. RA-affected patients exhibited considerably higher recurrence rates and elevated tissue eosinophil counts and percentages when compared to those without RA.
Recurrence was also linked to higher tissue eosinophil levels and a greater prevalence of allergic rhinitis. Multivariate analysis identified RA, tissue eosinophils, and allergic rhinitis as key predictors of recurrence, with RA independently increasing CRSwNP postoperative recurrence. Kaplan-Meier analysis further confirmed an amplified likelihood of relapse in CRSwNP people suffering from RA. These outcomes underscore the necessity for personalized therapeutic strategies for CRSwNP patients having RA.
Addressing eosinophilic infiltration and tailoring postoperative care could remarkably mitigate recurrence risks and boost patient outcomes. This research invites a closer examination of the RA-CRSwNP connection, opening pathways for innovative interventions that target underlying inflammatory mechanisms. A multidisciplinary approach targeting autoimmune factors and surgical complexities may benefit patients with both CRSwNP and RA. As RA emerges as an independent risk factor, collaborative care between rheumatologists and otolaryngologists becomes imperative.
Journal of Asthma and Allergy
Rheumatoid Arthritis Exacerbates Eosinophilic Inflammation Contributing to Postoperative Recurrence in Chronic Rhinosinusitis with Nasal Polyps
Yuan Yuan et al.
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