Lappaconitine and Ibuprofen combo best for pain relief after tonsil and adenoid surgery

In a recent study published in the “Journal of Perianesthesia Nursing”, adding a transdermal Lappaconitine (TLA) patch hastened analgesia for children undergoing adenoidectomy and tonsillectomy. Ibuprofen suspension (IS) alone was more effective than TLA alone, while combining TLA and IS offered the best pain relief.  In this randomized controlled prospective study, investigators compared the pain relief and side effects of three different analgesic regimens for patients (age 3 to 17 years) undergoing tonsil and adenoid excision.

The regimens included a TLA patch alone, IS alone, and a combination of both (TLACIS). In this prospective, randomized trial, 102 patients received the TLA patch, 101 received the IS, and 101 received the TLACIS combination. Pain levels were assessed at 2, 12, and 24 hours after operation, and adverse events were tracked for a week. At 2 hours, pain scores were significantly lower in the TLA and TLACIS groups compared to the IS group.

At 12 and 24 hours, the TLACIS group experienced the lowest pain scores, with the IS group also performing better than the TLA group. No notable differences were noted in adverse event rates among the three groups. For optimal pain relief after surgery, the TLACIS regimen (TLA patch plus IS) was the most effective, surpassing both TLA alone and IS alone. Additionally, all regimens had similar safety profiles, showing no pivotal difference in adverse events.